Efficacy and safety of 1% forskolin eye drops in open angle glaucoma - An open label study.
نویسندگان
چکیده
PURPOSE Current treatment for glaucoma includes beta-blockers and prostaglandin analogues which have their own disadvantages. Thus a need exists for new ocular hypotensive agents that are more efficacious and have fewer side effects. Therefore, forskolin eye drops 1%, through herbal product; a clinical trial was carried out for the safety and efficacy in the treatment of open angle glaucoma. METHODS Ninety adult male/female patients of 18-60 years of age, of either sex, suffering from open angle glaucoma with an intraocular pressure (IOP) of more than 24 mm Hg were enrolled in the study. Patients were advised to instill 2 drops thrice a day (8:00 h, 14:00 h and 20:00 h) and tonometric readings were recorded on baseline visit and on Visit 2, i.e. end of 1st week, Visit 3-2nd week, Visit 4-3rd week, and Visit 5-4th week. The reduction in IOP across each time point from untreated baseline visit and reduction in IOP across various study visits were measured. RESULTS The mean (95% CI) difference in reduction in IOP was 4.5 mm Hg (P < 0.05) in the right eye and was 5.4 mm Hg (p < 0.05) in the left eye from baseline visit (Visit 1) to final visit (Visit 5). CONCLUSIONS Forskolin 1% eye drops can be a safe alternative to beta blockers in glaucoma patients having concomitant asthma.
منابع مشابه
A Double-blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Forskolin Eye Drops 1% in the Treatment of Open Angle Glaucoma – A Comparative Study
Copyright: © 2014 Majeed M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. A Double-blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Forskolin Eye Drops 1% in the Treatment of Op...
متن کاملIntraocular Pressure Lowering Activity of Ocufors
Intra Ocular Pressure (IOP) is the fluid pressure inside the eye and is the most important risk factor for glaucoma. From the roots of Coleus forskohlii, an aromatic herb growing all over India, we extracted Forskolin. In this study we studied the IOP lowering activity of two strengths of Ocufors, viz., Ocufors (Forskolin 1% w/v ophthalmic solution) and Ocufors (Forskolin 0.15% w/v ophthalmic s...
متن کاملEfficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study
متن کامل
Safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% eye drops to brinzolamide 1.0%/timolol maleate 0.5% eye drops
PURPOSE To evaluate the safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% fixed-combination (DTFC) eye drops to brinzolamide 1.0%/timolol maleate 0.5% fixed-combination (BTFC) eye drops in patients with primary open-angle glaucoma or ocular hypertension. METHODS A total of 35 eyes of 35 patients with primary open-angle glaucoma or ocular hypertension using DTFC eye d...
متن کاملInter-Rater Agreement in the Assessment of Video Recordings of Eye Drop Instillation by Glaucoma Patients
PURPOSE To create a standardized method for evaluating the video recordings of patients self-instilling eye drops and to determine the level of agreement of eye drop instillation efficacy, safety and efficiency ratings by three masked graders. DESIGN Prospective cross-sectional study. PARTICIPANTS 78 patients with open-angle glaucoma or ocular hypertension who had at least 6 months of exper...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
دوره 29 3 شماره
صفحات -
تاریخ انتشار 2015